Table of Contents II Table of Contents VIII Introduction by the Scientiﬁc Director Prof. Luft Nikolaus Rajewsky Claus Scheidereit Book Design Printing Laserline, Berlin 2017 Credit: Julian Heuberger (Lab of Walter Birchmeier), Anje Sporbert (Advanced Light Microscopy (ALM) technology platform) Editorial Board Carmen Birchmeier Norbert Hübner Friedrich C.

Credit: Eric Metzler, PhD student (Lab of Simone Spuler) Technology Platforms: The 3-D-mouse embryo is a reconstruction made up of 360 individual images, the developing nervous system appears in orange. Myosin heavy chain (MyHC) protein of fused muscle cells is stained with a green fluorescent dye nuclei appear in blue. Credit: Christin Stottmeister (Lab of Nikolaus Rajewsky) ECRC: This image depicts human myoblasts and myotubes derived from a biopsy. CircRNAs in yellow next to the pink cell bodies with blue nuclei. Credit: Dominique Bröhl (formerly Lab of Carmen Birchmeier) Editors Vera Glaßer (Editor-in-chief) Jana Schlütter Stephanie Sturm BIMSB: Reminiscent of faraway galaxies: cancer cells found in malignant brain tumors produce circular RNA (circRNA), a type of molecule we know relatively little about. Muscle stem cells stained by an antibody against Pax7 (blue) are located under the basal lamina (green). Credit: Vanessa Schmidt (Lab of Thomas Willnow) Cancer Research: The colorful confetti of tumor cells which has been stained Credit: Matthias Leisegang (formerly Lab of Wolfgang Uckert) Research Report 2016 (covers the period 2014-2016) Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) Communications Department Robert-Rössle-Str.10 13125 Berlin Phone: +49-30-9406-0 Email: This Research Report is also available online: Diseases of the Nervous System: Under the microscope the cross-section of mouse skeletal muscle looks has a sponge-like structure. Nuclei are blue with different fluorescent dyes.

Insulin receptors appear red and early endosomes green. Cardiovascular and Metabolic Disease: These fireworks and balloons are fatty cells.

The cells are Credit: Gizem Inak (Lab of Erich Wanker, Group of Alessandro Prigione) Cover: What looks like coral reefs and brightly glowing fishes in this picture stained with a fluorescent dye (Lin28-DAPI). Image Captions are actually induced pluripotent stem cells in a pluripotency test.

Thirupugal govindarajan